Will I experience hair loss or liver damage after long-term use of retinoids? Mel J. November 05, 2021 12:41 No, there have been no side effects resulting from the long-term use of topical retinoids. Related articles Do retinoids thin your skin? Is this retinoid the same as Retin-A? How does it work? Using your refillable bottle Do retinoids help with fine lines and wrinkles?