Do retinoids help with hyperpigmentation? Mel J. November 05, 2021 12:33 Yes! Retinoids can improve mottled or irregular hyperpigmentation. Related articles Am I too old/too young to use retinoids? Can I use retinoids if I have dry or sensitive skin? Do retinoids make you more sensitive to the sun? What is the difference between retinoids and retinol? How long until I start seeing results?